Department of Cardiothoracic Surgery, Kings College Hospital, London, United Kingdom
* Address correspondence to Dr John, Department of Cardiothoracic Surgery, Kings College Hospital, Denmark Hill, London, SE5 9RS, United Kingdom .
The contribution of biomechanical factors to the incidence and
distribution of coronary artery and bypass graft disease is
underrecognized. This review examined the literature to determine
which factors were relevant and the evidence for their importance.
It identified two primary biomechanical factors that predispose
to disease: (1) low-wall shear stress and (2) high-wall mechanical
stress or strain. A range of secondary biomechanical factors
have also been identified and include: vessel geometry; vessel
movement; vessel wall characteristics and the presence of reflection
waves. Potential surgical approaches for minimizing these effects
are discussed.
Posts
Registration of your site
